Photochromic Fentanyl Derivatives for Controlled μ-Opioid Receptor Activation.
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ABSTRACT:
SUBMITTER: Lahmy R
PROVIDER: S-EPMC9826449 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Photochromic Fentanyl Derivatives for Controlled μ-Opioid Receptor Activation.
Lahmy Ranit R Hübner Harald H Schmidt Maximilian F MF Lachmann Daniel D Gmeiner Peter P König Burkhard B
Chemistry (Weinheim an der Bergstrasse, Germany) 20220912 63
Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant μ-opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have been developed in this work, modelled on the known agonist fentanyl, with the aim of expanding the cur ...[more]
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