Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mu Opioid Receptor 1 Expression and Activation Patterns in Colorectal Cancer

ABSTRACT: Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery.

DISEASE(S): Colorectal Surgery For Stage Ii / Iii Primary Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2336583 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Expression of Neutrophil-related genes in patients with early sepsis-induced ARDS

Project description:Clinical study of critically ill patients with sepsis and sepsis-related ARDS with whole blood RNA collected within the first 24 hours of admission Goal of the study was to determine whether biologically relevant genes were identified to be differentially expressed genes in patients with sepsis alone and sepsis with ARDS Prospective observational study, case cohort design

2015-04-01 | E-GEOD-66890 | biostudies-arrayexpress

Meta-analysis of Epigenome Wide Association Studies of Major Depressive Disorder

Project description:EPIC array data were generated from 2 MDD case control cohorts. EWAS was performed in each cohort, followed by meta-analysis between the 2 cohort. Cohort 1: A total of 191 blood samples from 112 patients with MDD was collected up till the interim analysis (wave 1 samples) from an observational clinical study OBSERVEMDD0001 (ClinicalTrials.gov Identifier: NCT02489305) compared to 32 healthy controls; Cohort 2: The MDD cases (N = 359) were drawn from the Molecular Biomarkers of Antidepressant Response study compared to 68 healthy controls.

2022-11-03 | GSE198904 | GEO

Project description:Pediatric WNT Medulloblastoma Predisposition in Intraoperative Blood Loss: a Retrospective Observational Cohort Study

| PRJNA1124362 | ENA

Peripheral Blood Gene Expression Signatures in Patients with Rheumatoid Arthritis

Project description:Observational study in cohort of patients with Rheumatoid Arthritis.

2022-12-04 | GSE141529 | GEO

Project description:Immunocompromised Patient Observational Cohort Study

| PRJNA1096689 | ENA

Significant Downregulation of Platelet Gene Expression in Metastatic Lung Cancer

Project description:Platelets have multiple roles in cancer cell metastasis. In this work we employed exon microarray technology to address platelet gene expression in metastatic non small cell lung cancer versus controls without cancer. We found that 197 of the 200 genes with the most significantly altered expression levels had their expression levels downregulated. Retrospective observational study. Total of 12 samples: 6 controls and 6 lung cancer samples.

2010-10-15 | E-GEOD-23361 | biostudies-arrayexpress

Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats.

Project description:Inflammation enhances the peripheral analgesic efficacy of opioid drugs, but the mechanisms involved in this phenomenon have not been fully elucidated. Crotalphine (CRP), a peptide that was first isolated from South American rattlesnake C.d. terrificus venom, induces a potent and long-lasting anti-nociceptive effect that is mediated by the activation of peripheral opioid receptors. Because the high efficacy of CRP is only observed in the presence of inflammation, we aimed to elucidate the mechanisms involved in the CRP anti-nociceptive effect induced by inflammation. Using real-time RT-PCR, western blot analysis and ELISA assays, we demonstrate that the intraplantar injection of prostaglandin E2 (PGE2) increases the mRNA and protein levels of the µ- and ?-opioid receptors in the dorsal root ganglia (DRG) and paw tissue of rats within 3 h of the injection. Using conformation state-sensitive antibodies that recognize activated opioid receptors, we show that PGE2, alone does not increase the activation of these opioid receptors but that in the presence of PGE2, the activation of specific opioid receptors by CRP and selective µ- and ?-opioid receptor agonists (positive controls) increases. Furthermore, PGE2 down-regulated the expression and activation of the ?-opioid receptor. CRP increased the level of activated mitogen-activated protein kinases in cultured DRG neurons, and this increase was dependent on the activation of protein kinase C?. This CRP effect was much more prominent when the cells were pretreated with PGE2. These results indicate that the expression and activation of peripheral opioid receptors by opioid-like drugs can be up- or down-regulated in the presence of an acute injury and that acute tissue injury enhances the efficacy of peripheral opioids.

| S-EPMC3942445 | biostudies-literature

Nasal gene expression in smokers, former smokers, and COPD subjects

Project description:Samples were derived from the non-interventional, observational, case-control study conducted in the UK. The study has been registered on ClinicalTrials.gov with identifier NCT01780298.

2015-06-30 | E-MTAB-4015 | biostudies-arrayexpress

Longitudinal gene expression profiling of self-collected blood samples in COVID-19+ and healthy participants

Project description:Longitudinal cohort: 773 host response genes were profiled in previously vaccinated (n=16) and unvaccinated (n=14) COVID-19+ participants along with 5 healthy uninfected controls across a 2-week observational window Single timepoint cohort: 773 host response genes were profiled in 6 healthy uninfected participants

2023-09-30 | GSE243348 | GEO

Genome-wide expression data of breast cancer samples

Project description:DASL gene expression data of fresh-frozen breast cancer tissue samples Retrospective cohort

2014-07-09 | E-GEOD-59198 | biostudies-arrayexpress