RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.
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ABSTRACT:
SUBMITTER: Luo R
PROVIDER: S-EPMC9828542 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
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RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.
Luo Rongjin R Liang Huaizhen H Zhang Weifeng W Li Gaocai G Zhao Kangcheng K Hua Wenbin W Song Yu Y Yang Cao C
Acta biochimica et biophysica Sinica 20220401 4
Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying ER-phagy in the pathogenesis of intervertebral disc degeneration remain largely unclear. In the present study, we demonstrated that RETREG1-mediated ER-phagy is induced by glucose deprivation (GD) treatment, along with ER stress activation and cell function decline. Importantly, ER-phagy was shown to be crucial for cell sur ...[more]
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