Ontology highlight
ABSTRACT:
SUBMITTER: Karjalainen T
PROVIDER: S-EPMC98308 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Karjalainen T T Waligora-Dupriet A J AJ Cerquetti M M Spigaglia P P Maggioni A A Mauri P P Mastrantonio P P
Infection and immunity 20010501 5
The gene slpA, encoding the S-layer precursor protein in the virulent Clostridium difficile strains C253 and 79--685, was identified. The precursor protein carries a C-terminal highly conserved anchoring domain, similar to the one found in the Cwp66 adhesin (previously characterized in strain 79--685), an SLH domain, and a variable N-terminal domain mediating cell adherence. The genes encoding the S-layer precursor proteins and the Cwp66 adhesin are present in a genetic locus carrying 17 open re ...[more]