Ontology highlight
ABSTRACT:
SUBMITTER: Martens AWJ
PROVIDER: S-EPMC9851097 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Martens Anne W J AWJ Kavazović Inga I Krapić Mia M Pack Su Min SM Arens Ramon R Jongejan Aldo A Moerland Perry D PD Eldering Eric E van der Windt Gerritje J W GJW Wensveen Felix M FM Peters Fleur S FS Kater Arnon P AP
Leukemia 20230119 3
T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional consequences of antigen-specific T-cell responses in presence of CLL in vitro and in an adoptive-transfer murine model. Already at steady-state, antigen-experienced patient-derived T cells were skewed towards short-lived effector cells (SLEC) at the ...[more]