Dataset Information

Associations between serum electrolyte and short-term outcomes in patients with acute decompensated heart failure.

ABSTRACT:

Introduction

There is a dearth of comprehensive studies on the association between serum electrolyte and adverse short-term prognosis of Chinese patients with acute decompensated heart failure (ADHF).

Patients and methods

A total of 5166 patients with ADHF were divided into four serum electrolyte-related study populations (potassium (n = 5145), sodium (n = 5135), chloride (n = 4966), serum total calcium (STC) (n = 4143)) under corresponding exclusions. Different logistic regression models were utilized to gauge the association between these electrolytes or the number of electrolyte abnormalities and the risk of a composite of all-cause mortality or 30-day heart failure (HF) readmission.

Results

In multivariable adjusted analysis, patients with potassium below 3.5 mmol/L (odds ratios (ORs) 1.45; 95% confidence interval (CI):1.07-1.95), 4.01-4.50 mmol/L (OR: 1.29, CI: 1.02-1.62), 4.51-5.00 mmol/L (OR: 1.43, CI: 1.08-1.90) and above 5.00 mmol/L (OR: 1.74, CI: 1.21-2.51) had an increased risk of outcome when compared with potassium at 3.50-4.00 mmol/L. Sodium levels were inversely related to the risk of a composite outcome (<130 mmol/L: OR: 2.73 (95% CI, 1.81-4.12); 130-134 mmol/L: OR, 1.97 (CI, 1.45-2.68); 135-140 mmol/L: OR, 1.45 (CI, 1.17-1.81); p for trend < 0.001) in comparison with sodium at 141-145 mmol/L. Chloride < 95 mmol/L corresponded to a higher risk of a composite outcome with an OR of 1.65 (95% CI, 1.16-2.37) in contrast to chloride levels at 101-105 mmol/L. In addition, the adjusted ORs (95% CI) for a composite outcome comparing the STC < 2.00 and 2.00-2.24 vs. 2.25-2.58 mmol/L were 0.98 (0.69-1.43) and 1.13 (0.89-1.44), respectively. Besides that, the number of electrolyte abnormalities was positively related to the risk of a composite outcome (N = 1, OR 1.40, 95% CI: 1.13-1.73; N = 2, OR 2.51, 95% CI: 1.85-3.42; N = 3, OR 2.47, 95% CI: 1.45-4.19; p for trend < 0.001) in comparison with N = 0.

Conclusions

A deviation of potassium levels from 3.50 to 4.00 mmol/L, lower sodium levels and hypochloremia were associated with poorer short-term prognosis of ADHF. Furthermore, the number of electrolyte abnormalities positively correlated with adverse short-term prognosis of patients with ADHF. Key MessagesADHF patients with baseline serum potassium at first half part of normal range (3.50-4.00 mmol/L) may herald the lowest risk of recent cardiovascular events.Serum sodium and chloride levels exhibit discrepancies in terms of risk of short-term adverse events of ADHF patients.The number of electrolyte abnormalities is a significant predictor of poor short-term prognosis in patients with ADHF.

Clinical trial registration url

http://www.chictr.org.cn/showproj.aspx?proj=23139. Unique identifier: ChiCTR-POC-17014020.

SUBMITTER: Zhao K

PROVIDER: S-EPMC9851236 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Associations between serum electrolyte and short-term outcomes in patients with acute decompensated heart failure.

Zhao Kai K Zheng Qun Q Zhou Jiang J Zhang Qi Q Gao Xiaoli X Liu Yinghua Y Li Senlin S Shan Weichao W Liu Li L Guo Nan N Tian Hongsen H Wei Qingmin Q Hu Xitian X Cui Yingkai Y Geng Xue X Wang Qian Q Cui Wei W

Annals of medicine 20231201 1

<h4>Introduction</h4>There is a dearth of comprehensive studies on the association between serum electrolyte and adverse short-term prognosis of Chinese patients with acute decompensated heart failure (ADHF).<h4>Patients and methods</h4>A total of 5166 patients with ADHF were divided into four serum electrolyte-related study populations (potassium (<i>n</i> = 5145), sodium (<i>n</i> = 5135), chloride (<i>n</i> = 4966), serum total calcium (STC) (<i>n</i> = 4143)) under corresponding exclusions. ...[more]

PMID: 36519243

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Dataset Information

Associations between serum electrolyte and short-term outcomes in patients with acute decompensated heart failure.

Introduction

Patients and methods

Results

Conclusions

Clinical trial registration url

Publications

Associations between serum electrolyte and short-term outcomes in patients with acute decompensated heart failure.

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