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Formation of Catalytic Hotspots in ATP-Templated Assemblies.

ABSTRACT: The self-assembly of surfactant-based structures that rely for their formation on the combination of a thermodynamically controlled and a dissipative pathway is described. Adenosine triphosphate (ATP) acts as a high-affinity template and triggers assembly formation at low surfactant concentrations. The presence of these assemblies creates the conditions for the activation of a dissipative self-assembly process by a weak-affinity substrate. The substrate-induced recruitment of additional surfactants leads to the spontaneous formation of catalytic hotspots in the ATP-stabilized assemblies that cleave the substrate. As a result of the two self-assembly processes, catalysis can be observed at a surfactant concentration at which low catalytic activity is observed in the absence of ATP.

SUBMITTER: Das K

PROVIDER: S-EPMC9853849 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Formation of Catalytic Hotspots in ATP-Templated Assemblies.

Das Krishnendu K Kar Haridas H Chen Rui R Fortunati Ilaria I Ferrante Camilla C Scrimin Paolo P Gabrielli Luca L Prins Leonard J LJ

Journal of the American Chemical Society 20221228 2

The self-assembly of surfactant-based structures that rely for their formation on the combination of a thermodynamically controlled and a dissipative pathway is described. Adenosine triphosphate (ATP) acts as a high-affinity template and triggers assembly formation at low surfactant concentrations. The presence of these assemblies creates the conditions for the activation of a dissipative self-assembly process by a weak-affinity substrate. The substrate-induced recruitment of additional surfacta ...[more]

PMID: 36576874

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