Therapeutic Strategies to Activate p53.
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ABSTRACT:
SUBMITTER: Aguilar A
PROVIDER: S-EPMC9866379 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Therapeutic Strategies to Activate p53.
Aguilar Angelo A Wang Shaomeng S
Pharmaceuticals (Basel, Switzerland) 20221224 1
The p53 protein has appropriately been named the "guardian of the genome". In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53. ...[more]
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