Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice.
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ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC9882976 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice.
Chen Dongxia D Guo Junnan J Li Ao A Sun Chengjie C Lin Huibin H Lin Hongyu H Yang Chaoyong C Wang Wei W Gao Jinhao J
Science advances 20230127 4
Real-time localization and microbial activity information of indigenous gut microbiota over an extended period of time remains a challenge with existing visualizing methods. Here, we report a metabolic fluorine labeling (MEFLA)-based strategy for monitoring the dynamic gut microbiota via <sup>19</sup>F magnetic resonance imaging (<sup>19</sup>F MRI). In situ labeling of different microbiota subgroups is achieved by using a panel of peptidoglycan-targeting MEFLA probes containing <sup>19</sup>F a ...[more]
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