Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC9898034 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Wang Xuepeng X Cooper Scott S Broxmeyer Hal E HE Kapur Reuben R
Leukemia 20221202 2
Enhancing the efficiency of hematopoietic stem cell (HSC) homing and engraftment is critical for cord blood (CB) hematopoietic cell transplantation (HCT). Recent studies indicate that N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modulates the expression of mRNAs that are critical for stem cell function by influencing their stability. Here, we demonstrate that inhibition of RNA decay by regulation of RNA methylation, enhances the expression of the homing receptor chemokine C-X-C receptor-4 (CXC ...[more]