N -arylpyrazole NOD2 agonists promote immune checkpoint inhibitor therapy.
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ABSTRACT:
SUBMITTER: Griffin ME
PROVIDER: S-EPMC9901186 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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<i>N</i> -arylpyrazole NOD2 agonists promote immune checkpoint inhibitor therapy.
Griffin Matthew E ME Tsukidate Taku T Hang Howard C HC
bioRxiv : the preprint server for biology 20230127
The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on <i>Enterococcus</i> species revealed peptidoglycan remodeling and activation of NOD2 as key mechanisms for microbiota enhancement of immune checkpoint inhibitor therapy. Inspired by this work and other studies of NOD2 activation, we performed <i>in silico</i> ligand screening and developed <i>N</i> -arylpyrazole ...[more]
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