Ontology highlight
ABSTRACT:
SUBMITTER: Biel D
PROVIDER: S-EPMC9906389 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Biel Davina D Suárez-Calvet Marc M Hager Paul P Rubinski Anna A Dewenter Anna A Steward Anna A Roemer Sebastian S Ewers Michael M Haass Christian C Brendel Matthias M Franzmeier Nicolai N
EMBO molecular medicine 20230109 2
Microglial activation occurs early in Alzheimer's disease (AD) and previous studies reported both detrimental and protective effects of microglia on AD progression. Here, we used CSF sTREM2 to investigate disease stage-dependent drivers of microglial activation and to determine downstream consequences on AD progression. We included 402 patients with measures of earliest beta-amyloid (CSF Aβ<sub>1-42</sub> ) and late-stage fibrillary Aβ pathology (amyloid-PET centiloid), as well as sTREM2, p-tau< ...[more]