Ontology highlight
ABSTRACT:
SUBMITTER: Goo BS
PROVIDER: S-EPMC9908555 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Goo Bon Seong BS Mun Dong Jin DJ Kim Seunghyun S Nhung Truong Thi My TTM Lee Su Been SB Woo Youngsik Y Kim Soo Jeong SJ Suh Bo Kyoung BK Park Sung Jin SJ Lee Hee-Eun HE Park Kunyou K Jang Hyunsoo H Rah Jong-Cheol JC Yoon Ki-Jun KJ Baek Seung Tae ST Park Seung-Yeol SY Park Sang Ki SK
Molecular psychiatry 20221110 2
Although large-scale genome-wide association studies (GWAS) have identified an association between MAD1L1 (Mitotic Arrest Deficient-1 Like 1) and the pathology of schizophrenia, the molecular mechanisms underlying this association remain unclear. In the present study, we aimed to address these mechanisms by examining the role of MAD1 (the gene product of MAD1L1) in key neurodevelopmental processes in mice and human organoids. Our findings indicated that MAD1 is highly expressed during active cor ...[more]