Ontology highlight
ABSTRACT:
SUBMITTER: Jossin Y
PROVIDER: S-EPMC3102785 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Jossin Yves Y Cooper Jonathan A JA
Nature neuroscience 20110424 6
Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipolar neurons to polarize their migration toward the cortical plate. Inhibition and rescue experiments indicated that Reelin regulates migration through Rap1 and Akt, and that the Rap1 ...[more]