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Towards the Standardization of Photothermal Measurements of Iron Oxide Nanoparticles in Two Biological Windows.

ABSTRACT: A systematic study on laser-induced heating carried out in two biological windows (800 nm and 1053 nm) for Fe₃O₄ nanoparticles in water suspension showed evidence of the strong dependence of the specific absorption rate (SAR) on extrinsic parameters such as the vessel volume or laser spot size. The results show that a minimum of 100 μL must be used in order to obtain vessel-size-independent SARs. In addition, at a constant intensity but different laser powers and spot size ratios, the SARs can differ by a three-fold factor, showing that the laser power and irradiated area strongly affect the heating curves for both wavelengths. The infrared molecular absorber IRA 980B was characterized under the same experimental conditions, and the results confirm the universality of the SARs' dependence on these extrinsic parameters. Based on these results, we propose using solutions of IRA 980B as a standard probe for SAR measurements and employing the ratio SAR_{iron oxide}/SAR_{IRA 980B} to compare different measurements performed in different laboratories. This measurement standardization allows us to extract more accurate information about the heating performance of different nanoparticles.

SUBMITTER: Arranz D

PROVIDER: S-EPMC9921180 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Towards the Standardization of Photothermal Measurements of Iron Oxide Nanoparticles in Two Biological Windows.

Arranz Daniel D Weigand Rosa R de la Presa Patricia P

Nanomaterials (Basel, Switzerland) 20230122 3

A systematic study on laser-induced heating carried out in two biological windows (800 nm and 1053 nm) for Fe<sub>3</sub>O<sub>4</sub> nanoparticles in water suspension showed evidence of the strong dependence of the specific absorption rate (SAR) on extrinsic parameters such as the vessel volume or laser spot size. The results show that a minimum of 100 μL must be used in order to obtain vessel-size-independent SARs. In addition, at a constant intensity but different laser powers and spot size ...[more]

PMID: 36770411

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Project description:Magnetic nanoparticles (NPs) are powerful agents to induce hyperthermia in tumours upon the application of an alternating magnetic field or an infrared laser. Dopants have been investigated to alter different properties of materials. Herein, the effect of zinc doping into iron oxide NPs on their magnetic properties and structural characteristics has been investigated in-depth. A high temperature reaction with autogenous pressure was used to prepare iron oxide and zinc ferrite NPs of same size and morphology for direct comparison. Pressure was key in obtaining high quality nanocrystals with reduced lattice strain (27% less) and enhanced magnetic properties. Zn0.4Fe2.6O4 NPs with small size of 10.2 ± 2.5 nm and very high saturation magnetisation of 142 ± 9 emu gFe+Zn-1 were obtained. Aqueous dispersion of the NPs showed long term magnetic (up to 24 months) and colloidal stability (at least 6 d) at physiologically mimicking conditions. The samples had been kept in the fridge and had been stable for four years. The biocompatibility of Zn0.4Fe2.6O4 NPs was next evaluated by metabolic activity, membrane integrity and clonogenic assays, which show an equivalence to that of iron oxide NPs. Zinc doping decreased the bandgap of the material by 22% making it a more efficient photothermal agent than iron oxide-based ones. Semiconductor photo-hyperthermia was shown to outperform magneto-hyperthermia in cancer cells, reaching the same temperature 17 times faster whilst using 20 times less material (20 mgFe+Zn ml-1vs. 1 mgFe+Zn ml-1). Magnetothermal conversion was minimally hindered in the cellular confinement whilst photothermal efficiency remained unchanged. Photothermia treatment alone achieved 100% cell death after 10 min of treatment compared to only 30% cell death achieved with magnetothermia at clinically relevant settings for each at their best performing concentration. Altogether, these results suggest that the biocompatible and superparamagnetic zinc ferrite NPs could be a next biomaterial of choice for photo-hyperthermia, which could outperform current iron oxide NPs for magnetic hyperthermia.

Dataset Information

Towards the Standardization of Photothermal Measurements of Iron Oxide Nanoparticles in Two Biological Windows.

Publications

Towards the Standardization of Photothermal Measurements of Iron Oxide Nanoparticles in Two Biological Windows.

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