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NAD⁺-Consuming Enzymes in Stem Cell Homeostasis.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD⁺ is also required as a cofactor by nonredox NAD⁺-dependent enzymes. Hundreds of enzymes that consume NAD⁺ have been identified. The NAD⁺-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, we discussed how different types of NAD⁺-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD⁺ consumers in SC homeostasis. We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis via the regulation of the NAD⁺-consuming enzymes.

SUBMITTER: Ji X

PROVIDER: S-EPMC9931471 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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NAD+-Consuming Enzymes in Stem Cell Homeostasis.

Ji Xiuna X Zheng Mingyue M Yu Tao T Kang Jie J Fan Tingjun T Xu Bin B

Oxidative medicine and cellular longevity 20230208

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD+ is also required as a cofactor by nonredox NAD+-dependent enzymes. Hundreds of enzymes that consume NAD+ have been identified. The NAD+-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, ...[more]

PMID: 36819783

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