Ontology highlight
ABSTRACT:
SUBMITTER: Warrender AK
PROVIDER: S-EPMC9951194 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Warrender Annmaree K AK Pan Jolyn J Pudney Chris R CR Arcus Vickery L VL Kelton William W
Protein science : a publication of the Protein Society 20230301 3
The constant regions of clinical monoclonal antibodies are derived from a select number of allotypes found in IgG subclasses. Despite a long-term acknowledgment that this diversity may impact both antibody function and developability, there is a lack of data on the stability of variants carrying these mutations. Here, we generated a panel of IgG1, IgG2, and IgG3 antibodies with 32 unique constant region alleles and performed a systematic comparison of stability using red edge excitation shift (R ...[more]