An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science.
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ABSTRACT:
SUBMITTER: Fairman K
PROVIDER: S-EPMC9964742 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science.
Fairman Kiara K Choi Me-Kyoung MK Gonnabathula Pavani P Lumen Annie A Worth Andrew A Paini Alicia A Li Miao M
Toxics 20230128 2
A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models are used in the pharmaceutical sector for drug development, precision medicine, and the chemical industry to predict safe levels of exposure during the registration of chemical substances. However, one area of application where PBPK models have ...[more]
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