Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC9984961 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Chen Xizhao X Li Mansheng M Zhu Songbiao S Lu Yang Y Duan Shuwei S Wang Xu X Wang Yong Y Chen Pu P Wu Jie J Wu Di D Feng Zhe Z Cai Guangyan G Zhu Yunping Y Deng Haiteng H Chen Xiangmei X
iScience 20230113 3
IgA nephropathy (IgAN) is a heterogeneous disease, which poses a series of challenges to accurate diagnosis and personalized therapy. Herein, we constructed a systematic quantitative proteome atlas from 59 IgAN and 19 normal control donors. Consensus sub-clustering of proteomic profiles divided IgAN into three subtypes (IgAN-C1, C2, and C3). IgAN-C2 had similar proteome expression patterns with normal control, while IgAN-C1/C3 exhibited higher level of complement activation, more severe mitochon ...[more]