Unknown

Dataset Information

0

Levels of hormones regulating appetite and energy homeostasis in response to a 1.5-Year combined lifestyle intervention for obesity.


ABSTRACT: Background: Weight loss can induce changes in appetite-regulating hormone levels, possibly linked to increases in appetite and weight regain. However, hormonal changes vary across interventions. Here, we studied levels of appetite-regulating hormones during a combined lifestyle intervention (CLI: healthy diet, exercise and cognitive behavioral therapy). Methods: We measured levels of long-term adiposity-related hormones (leptin, insulin, high-molecular-weight (HMW) adiponectin) and short-term appetite hormones (PYY, cholecystokinin, gastric-inhibitory polypeptide, pancreatic polypeptide, FGF21, AgRP) in overnight-fasted serum of 39 patients with obesity. Hormone levels were compared between T0 (baseline), T1 (after 10 weeks) and T2 (end of treatment, 1.5 years). T0-T1 hormone changes were correlated with T1-T2 anthropometric changes. Results: Initial weight loss at T1 was maintained at T2 (-5.0%, p < 0.001), and accompanied by decreased leptin and insulin levels at T1 and T2 (all p < 0.05) compared to T0. Most short-term signals were not affected. Only PP levels were decreased at T2 compared to T0 (p < 0.05). Most changes in hormone levels during initial weight loss did not predict subsequent changes in anthropometrics, except for T0-T1 decreases in FGF21 levels and T0-T1 increases in HMW adiponectin levels tended to be associated with larger T1-T2 increases in BMI (p < 0.05 and p = 0.05, respectively). Conclusion: CLI-induced weight loss was associated with changes in levels of long-term adiposity-related hormones towards healthy levels, but not with orexigenic changes in most short-term appetite signals. Our data indicates that the clinical impact of alterations in appetite-regulating hormones during modest weight loss remains questionable. Future studies should investigate potential associations of weight-loss-induced changes in FGF21 and adiponectin levels with weight regain.

SUBMITTER: Kuckuck S 

PROVIDER: S-EPMC9986487 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

Levels of hormones regulating appetite and energy homeostasis in response to a 1.5-Year combined lifestyle intervention for obesity.

Kuckuck Susanne S   van der Valk Eline S ES   Scheurink Anton J W AJW   Lengton Robin R   Mohseni Mostafa M   Visser Jenny A JA   Iyer Anand M AM   van den Berg Sjoerd A A SAA   van Rossum Elisabeth F C EFC  

Frontiers in physiology 20230220


<b>Background:</b> Weight loss can induce changes in appetite-regulating hormone levels, possibly linked to increases in appetite and weight regain. However, hormonal changes vary across interventions. Here, we studied levels of appetite-regulating hormones during a combined lifestyle intervention (CLI: healthy diet, exercise and cognitive behavioral therapy). <b>Methods:</b> We measured levels of long-term adiposity-related hormones (leptin, insulin, high-molecular-weight (HMW) adiponectin) and  ...[more]

Similar Datasets

| S-EPMC9716348 | biostudies-literature
| S-EPMC10327278 | biostudies-literature
| S-EPMC4195273 | biostudies-literature
| S-EPMC7903013 | biostudies-literature
| S-EPMC10574110 | biostudies-literature
| S-EPMC7126273 | biostudies-literature
| S-EPMC6770918 | biostudies-literature
| S-EPMC1904154 | biostudies-literature
| S-EPMC2940837 | biostudies-literature
| S-EPMC5223036 | biostudies-literature