Dataset Information

Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.

ABSTRACT:

Background

Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term.

Material/methods

Infants born <28 weeks gestational age (GA) were included. Endogenous levels of insulin-like growth factor (IGF)-1, brain-derived growth factor, vascular endothelial growth factor, and platelet-derived growth factor (expressed as area under the curve [AUC] for serum samples from postnatal days 1, 7, 14, and 28) were utilized in a multivariable linear regression model. Brain volumes were determined by magnetic resonance imaging (MRI) at term equivalent age.

Results

In total, 49 infants (median [range] GA 25.4 [22.9-27.9] weeks) were included following MRI segmentation quality assessment and AUC calculation. IGF-1 levels were independently positively associated with the total brain (p < 0.001, β = 0.90), white matter (p = 0.007, β = 0.33), cortical gray matter (p = 0.002, β = 0.43), deep gray matter (p = 0.008, β = 0.05), and cerebellar (p = 0.006, β = 0.08) volume adjusted for GA at birth and postmenstrual age at MRI. No associations were seen for other growth factors.

Conclusions

Endogenous exposure to IGF-1 during the first 4 weeks of life was associated with total and regional brain volumes at term. Optimizing levels of IGF-1 might improve brain growth in extremely preterm infants.

Impact

High serum levels of insulin-like growth factor (IGF)-1 during the first month of life were independently associated with increased total brain volume, white matter, gray matter, and cerebellar volume at term equivalent age in extremely preterm infants. IGF-1 is a critical regulator of neurodevelopment and postnatal levels are low in preterm infants. The effects of IGF-1 levels on brain development in extremely preterm infants are not fully understood. Optimizing levels of IGF-1 may benefit early brain growth in extremely preterm infants. The effects of systemically administered IGF-1/IGFBP3 in extremely preterm infants are now being investigated in a randomized controlled trial (Clinicaltrials.gov: NCT03253263).

SUBMITTER: Hellstrom W

PROVIDER: S-EPMC9988684 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.

Hellström William W Hortensius Lisa M LM Löfqvist Chatarina C Hellgren Gunnel G Tataranno Maria Luisa ML Ley David D Benders Manon J N L MJNL Hellström Ann A Björkman-Burtscher Isabella M IM Heckemann Rolf A RA Sävman Karin K

Pediatric research 20220609 3

<h4>Background</h4>Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term.<h4>Material/methods</h4>Infants born <28 weeks gestational age (GA) were included. Endogenous levels of insulin-like growth factor (IGF)-1, brain-derived growth factor, vascular endothelial growth factor, and platelet-derived growth factor (expressed as area under the curve [AUC] for serum samples from post ...[more]

PMID: 35681088

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Dataset Information

Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.

Background

Material/methods

Results

Conclusions

Impact

Publications

Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.

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