Ontology highlight
ABSTRACT:
SUBMITTER: Zhong JY
PROVIDER: S-EPMC9988853 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Zhong Jia-Yong JY Niu Longjian L Lin Zhuo-Bin ZB Bai Xin X Chen Ying Y Luo Feng F Hou Chunhui C Xiao Chuan-Le CL
Nature communications 20230306 1
Canonical three-dimensional (3D) genome structures represent the ensemble average of pairwise chromatin interactions but not the single-allele topologies in populations of cells. Recently developed Pore-C can capture multiway chromatin contacts that reflect regional topologies of single chromosomes. By carrying out high-throughput Pore-C, we reveal extensive but regionally restricted clusters of single-allele topologies that aggregate into canonical 3D genome structures in two human cell types. ...[more]