Other

Dataset Information

0

Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State During Somatic Cell Reprogramming


ABSTRACT: The pluripotent genome is folded in a hierarchy of sophisticated topologies that markedly reconfigure during cell fate transitions. A critical unknown is whether chromatin folding is reversible and functionally linked to the re-establishment of pluripotency in somatic cell reprogramming. Here we integrate classic epigenetic marks with high-resolution architecture maps in embryonic stem (ES) cells, ES-derived neural progenitor cells (NPCs) and NPC-derived induced pluripotent stem (iPS) cells. Collectively we demonstrate that chromatin architecture is only partially reconfigured during somatic cell reprogramming and that pluripotent elements can retain architectural memory from their somatic cell of origin.

ORGANISM(S): Mus musculus

PROVIDER: GSE68582 | GEO | 2016/05/05

SECONDARY ACCESSION(S): PRJNA283133

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-04-06 | PXD023547 | Pride
2016-03-01 | E-GEOD-76480 | biostudies-arrayexpress
2016-03-01 | E-GEOD-76479 | biostudies-arrayexpress
2009-08-03 | GSE16925 | GEO
2010-05-13 | GSE21515 | GEO
2011-05-07 | E-GEOD-29102 | biostudies-arrayexpress
2009-07-02 | E-GEOD-15775 | biostudies-arrayexpress
2009-08-08 | E-GEOD-16925 | biostudies-arrayexpress
2010-05-28 | E-GEOD-21515 | biostudies-arrayexpress
2022-03-25 | GSE164786 | GEO