Focused Ion Beam-Scanning Electron Microscopy of mitochondrial reticulum in murine skeletal muscle
Ontology highlight
ABSTRACT:
SUBMITTER: Sriram Subramaniam
PROVIDER: EMPIAR-10070 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Mitochondrial reticulum for cellular energy distribution in muscle.
Glancy Brian B Hartnell Lisa M LM Malide Daniela D Yu Zu-Xi ZX Combs Christian A CA Connelly Patricia S PS Subramaniam Sriram S Balaban Robert S RS
Nature 20150701 7562
Intracellular energy distribution has attracted much interest and has been proposed to occur in skeletal muscle via metabolite-facilitated diffusion; however, genetic evidence suggests that facilitated diffusion is not critical for normal function. We hypothesized that mitochondrial structure minimizes metabolite diffusion distances in skeletal muscle. Here we demonstrate a mitochondrial reticulum providing a conductive pathway for energy distribution, in the form of the proton-motive force, thr ...[more]
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