Cryo EM of Type VI Secretion System VipA-N3/VipB/Hcp complex
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ABSTRACT:
SUBMITTER: Jing Wang
PROVIDER: EMPIAR-10086 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the extended type VI secretion system sheath-tube complex.
Wang Jing J Brackmann Maximilian M Castaño-Díez Daniel D Kudryashev Mikhail M Goldie Kenneth N KN Maier Timm T Stahlberg Henning H Basler Marek M
Nature microbiology 20170925 11
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a tube with associated effectors across membranes of eukaryotic and bacterial cells <sup>1-5</sup> . Only limited structural information is available about the inherently unstable precontraction state of the T6SS. Here, we obtain a 3.7 Å resolution structure of a non-contractile sheath-tube complex using cryo-electron microscopy and show that it resembles the extended T6SS inside Vibrio cholerae cel ...[more]
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