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Human TRPM4 ion channel in a lipid nanodisc in a calcium-bound state

ABSTRACT:

SUBMITTER: Henriette Elisabeth Autzen

PROVIDER: EMPIAR-10127 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure of the human TRPM4 ion channel in a lipid nanodisc.

Autzen Henriette E HE Myasnikov Alexander G AG Campbell Melody G MG Asarnow Daniel D Julius David D Cheng Yifan Y

Science (New York, N.Y.) 20171207 6372

Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation channel associated with a variety of cardiovascular disorders. TRPM4 is activated by increased intracellular calcium in a voltage-dependent manner but, unlike many other TRP channels, is permeable to monovalent cations only. Here we present two structures of full-length human TRPM4 embedded in lipid nanodiscs at ~3-angstrom resolution, as determined by single-particle cryo-electron microscopy. These structures, ...[more]

PMID: 29217581

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