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AP2 bound to MSP1 lipid nanodisc

ABSTRACT:

SUBMITTER: Richard Wayne Baker

PROVIDER: EMPIAR-11455 | biostudies-other |

REPOSITORIES: biostudies-other

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Lipid nanodiscs as a template for high-resolution cryo-EM structures of peripheral membrane proteins.

S Cannon Kevin K Sarsam Reta D RD Tedamrongwanish Tanita T Zhang Kevin K Baker Richard W RW

Journal of structural biology 20230624 3

Peripheral membrane proteins are ubiquitous throughout cell biology and are required for a variety of cellular processes such as signal transduction, membrane trafficking, and autophagy. Transient binding to the membrane has a profound impact on protein function, serving to induce conformational changes and alter biochemical and biophysical parameters by increasing the local concentration of factors and restricting diffusion to two dimensions. Despite the centrality of the membrane in serving as ...[more]

PMID: 37364761

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