A multi-scale model of the yeast chromosome-segregation system
Ontology highlight
ABSTRACT:
SUBMITTER: Lu Gan
PROVIDER: EMPIAR-10159 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Electron cryotomography analysis of Dam1C/DASH at the kinetochore-spindle interface in situ.
Ng Cai Tong CT Deng Li L Chen Chen C Lim Hong Hwa HH Shi Jian J Surana Uttam U Gan Lu L
The Journal of cell biology 20181130 2
In dividing cells, depolymerizing spindle microtubules move chromosomes by pulling at their kinetochores. While kinetochore subcomplexes have been studied extensively in vitro, little is known about their in vivo structure and interactions with microtubules or their response to spindle damage. Here we combine electron cryotomography of serial cryosections with genetic and pharmacological perturbation to study the yeast chromosome segregation machinery in vivo. Each kinetochore microtubule has on ...[more]
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