Ontology highlight
ABSTRACT:
SUBMITTER: Youdong Jack Mao
PROVIDER: EMPIAR-10163 | biostudies-other |
REPOSITORIES: biostudies-other
Zhang Shijian S Wang Kunyu K Wang Wei Li WL Nguyen Hanh T HT Chen Shuobing S Lu Maolin M Go Eden P EP Ding Haitao H Steinbock Robert T RT Desaire Heather H Kappes John C JC Sodroski Joseph J Mao Youdong Y
Journal of virology 20210922 24
The functional human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer [(gp120/gp41)<sub>3</sub>] is produced by cleavage of a conformationally flexible gp160 precursor. gp160 cleavage or the binding of BMS-806, an entry inhibitor, stabilizes the pretriggered, "closed" (state 1) conformation recognized by rarely elicited broadly neutralizing antibodies. Poorly neutralizing antibodies (pNAbs) elicited at high titers during natural infection recognize more "open" Env conformations ...[more]