Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC5472438 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
eLife 20170526
The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH3 to penetrate the Env glycan shield. Here we characterized a distinct mode of V1V2 epitope recognition by the new bNAb BG1 in which two Fa ...[more]