Dataset Information
Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses
Ontology highlight
ABSTRACT:
SUBMITTER: James Alexander Geraets
PROVIDER: EMPIAR-10199 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses.
PLoS biology 20190611 6
Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are "capsid binders" that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo-electron microscopy (EM), followed by resistance selection and reverse genetics, we discovered a hitherto unknown druggable pocket that is formed by viral proteins VP1 and VP3 and that is conserved across entero-/rhinoviru ...[more]
