Dataset Information
Mouse MDA5-dsRNA 2.5-mM AMPPNP Filamemt
Ontology highlight
ABSTRACT:
SUBMITTER: Yorgo Modis
PROVIDER: EMPIAR-10209 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Molecular cell 20181115 6
Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. Long cytosolic dsRNA is recognized by MDA5. The cooperative assembly of MDA5 into helical filaments on dsRNA nucleates the assembly of a multiprotein type I interferon signaling platform. Here, we determined cryoelectron microscopy (cryo-EM) structures of MDA5-dsRNA filaments with different helical twists and bound nucleotide analogs at resolutions sufficient to build and refine atomic models. The structures id ...[more]