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Mouse MDA5-dsRNA Filaments in presence of 1mM AMPPNP

ABSTRACT:

SUBMITTER: Yorgo Modis 

PROVIDER: EMPIAR-10213 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.

Yu Qin Q   Qu Kun K   Modis Yorgo Y  

Molecular cell 20181115 6

Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. Long cytosolic dsRNA is recognized by MDA5. The cooperative assembly of MDA5 into helical filaments on dsRNA nucleates the assembly of a multiprotein type I interferon signaling platform. Here, we determined cryoelectron microscopy (cryo-EM) structures of MDA5-dsRNA filaments with different helical twists and bound nucleotide analogs at resolutions sufficient to build and refine atomic models. The structures id  ...[more]

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