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Cryo-EM reconstruction of heparin-induced 2N4R tau filaments

ABSTRACT:

SUBMITTER: Sjors H.W. Scheres

PROVIDER: EMPIAR-10243 | biostudies-other |

REPOSITORIES: biostudies-other

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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.

Zhang Wenjuan W Falcon Benjamin B Murzin Alexey G AG Fan Juan J Crowther R Anthony RA Goedert Michel M Scheres Sjors Hw SH

eLife 20190205

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer's and Pick's diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments that were assembled from recombinant full-length human tau with four (2N4R) or three (2N3R) microtubule-binding repeats in the presence of heparin. 2N4R tau assembles into multiple types of filaments, and the structure ...[more]

PMID: 30720432

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