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Cryo-EM reconstruction of tau filaments extracted from the brains of three individuals with Corticobasal degeneration


ABSTRACT:

SUBMITTER: Sjors H.W. Scheres 

PROVIDER: EMPIAR-10340 | biostudies-other |

REPOSITORIES: biostudies-other

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Corticobasal degeneration (CBD) is a neurodegenerative tauopathy-a class of disorders in which the tau protein forms insoluble inclusions in the brain-that is characterized by motor and cognitive disturbances<sup>1-3</sup>. The H1 haplotype of MAPT (the tau gene) is present in cases of CBD at a higher frequency than in controls<sup>4,5</sup>, and genome-wide association studies have identified additional risk factors<sup>6</sup>. By histology, astrocytic plaques are diagnostic of CBD<sup>7,8</su  ...[more]

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