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Cryo-EM reconstruction of tau filaments extracted from the brains of three individuals with Corticobasal degeneration

ABSTRACT:

SUBMITTER: Sjors H.W. Scheres

PROVIDER: EMPIAR-10340 | biostudies-other |

REPOSITORIES: biostudies-other

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Novel tau filament fold in corticobasal degeneration.

Zhang Wenjuan W Tarutani Airi A Newell Kathy L KL Murzin Alexey G AG Matsubara Tomoyasu T Falcon Benjamin B Vidal Ruben R Garringer Holly J HJ Shi Yang Y Ikeuchi Takeshi T Murayama Shigeo S Ghetti Bernardino B Hasegawa Masato M Goedert Michel M Scheres Sjors H W SHW

Nature 20200212 7802

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy-a class of disorders in which the tau protein forms insoluble inclusions in the brain-that is characterized by motor and cognitive disturbances1-3. The H1 haplotype of MAPT (the tau gene) is present in cases of CBD at a higher frequency than in controls4,5, and genome-wide association studies have identified additional risk factors6. By histology, astrocytic plaques are diagnostic of CBD7,8</su ...[more]

PMID: 32050258

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