Cryo electron microscopy of TssA protein from T6SS of Vibrio cholerae.
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ABSTRACT:
SUBMITTER: Sergey Nazarov
PROVIDER: EMPIAR-10271 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems.
Schneider Johannes Paul JP Nazarov Sergey S Adaixo Ricardo R Liuzzo Martina M Ringel Peter David PD Stahlberg Henning H Basler Marek M
The EMBO journal 20190812 18
Protein translocation by the bacterial type VI secretion system (T6SS) is driven by a rapid contraction of a sheath assembled around a tube with associated effectors. Here, we show that TssA-like or TagA-like proteins with a conserved N-terminal domain and varying C-terminal domains can be grouped into at least three distinct classes based on their role in sheath assembly. The proteins of the first class increase speed and frequency of sheath assembly and form a stable dodecamer at the distal en ...[more]
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