Cryo-EM structure of the mammalian ATP synthase tetramer bound to inhibitory protein IF1 (Part1)
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ABSTRACT:
SUBMITTER: Maojun Yang
PROVIDER: EMPIAR-10283 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1.
Gu Jinke J Zhang Laixing L Zong Shuai S Guo Runyu R Liu Tianya T Yi Jingbo J Wang Peiyi P Zhuo Wei W Yang Maojun M
Science (New York, N.Y.) 20190601 6445
The mitochondrial adenosine triphosphate (ATP) synthase produces most of the ATP required by mammalian cells. We isolated porcine tetrameric ATP synthase and solved its structure at 6.2-angstrom resolution using a single-particle cryo-electron microscopy method. Two classical V-shaped ATP synthase dimers lie antiparallel to each other to form an H-shaped ATP synthase tetramer, as viewed from the matrix. ATP synthase inhibitory factor subunit 1 (IF1) is a well-known in vivo inhibitor of mammalian ...[more]
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