Ontology highlight
ABSTRACT:
SUBMITTER: Maojun Yang
PROVIDER: EMPIAR-10283 | biostudies-other |
REPOSITORIES: biostudies-other
Science (New York, N.Y.) 20190601 6445
The mitochondrial adenosine triphosphate (ATP) synthase produces most of the ATP required by mammalian cells. We isolated porcine tetrameric ATP synthase and solved its structure at 6.2-angstrom resolution using a single-particle cryo-electron microscopy method. Two classical V-shaped ATP synthase dimers lie antiparallel to each other to form an H-shaped ATP synthase tetramer, as viewed from the matrix. ATP synthase inhibitory factor subunit 1 (IF1) is a well-known in vivo inhibitor of mammalian ...[more]