Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations
Ontology highlight
ABSTRACT: Setd2 methylate the nucleosome to form H3K36me3. Here we utilized the Cryo-EM to elucidate the structure of SETD2/Set2 bound with nucleosomes. Through this structure analysis, we found that histone H1 may interfere the enzymatic activity of SETD2/Set2 by inhibiting their binding affinity.
ORGANISM(S): Homo sapiens
PROVIDER: GSE148235 | GEO | 2021/05/20
REPOSITORIES: GEO
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