Cryo electron microscopy of Cannabinoid Receptor 1-G Protein Complex
Ontology highlight
ABSTRACT:
SUBMITTER: Georgios Skiniotis
PROVIDER: EMPIAR-10288 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Krishna Kumar Kaavya K Shalev-Benami Moran M Robertson Michael J MJ Hu Hongli H Banister Samuel D SD Hollingsworth Scott A SA Latorraca Naomi R NR Kato Hideaki E HE Hilger Daniel D Maeda Shoji S Weis William I WI Farrens David L DL Dror Ron O RO Malhotra Sanjay V SV Kobilka Brian K BK Skiniotis Georgios G
Cell 20190110 3
Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor 1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein G<sub>i</sub>. Activation of CB1-G<sub>i</sub> signaling pathways holds potential for treating a number of neurological disorders and is thus crucial to understand the mechanism of G<sub>i</sub> activation by CB1. Here, we present the structure of the CB1-G<sub>i</sub> signal ...[more]
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