Cryo-electron microscopy Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex
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ABSTRACT:
SUBMITTER: Xiang-Qun Xie
PROVIDER: EMPIAR-11879 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-G<sub>i</sub> Signaling Complex.
Xing Changrui C Zhuang Youwen Y Xu Ting-Hai TH Feng Zhiwei Z Zhou X Edward XE Chen Maozi M Wang Lei L Meng Xing X Xue Ying Y Wang Junmei J Liu Heng H McGuire Terence Francis TF Zhao Gongpu G Melcher Karsten K Zhang Cheng C Xu H Eric HE Xie Xiang-Qun XQ
Cell 20200130 4
Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the human CB2-G<sub>i</sub> signaling complex bound to the agonist WIN 55,212-2. The 3D structure reveals the binding mode of WIN 55,212-2 and structural determinants for distinguishing ...[more]
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