Cryo-EM structure of multidrug efflux pump MexAB-OprM
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ABSTRACT:
SUBMITTER: Eiki Yamashita
PROVIDER: EMPIAR-10292 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Tsutsumi Kenta K Yonehara Ryo R Ishizaka-Ikeda Etsuko E Miyazaki Naoyuki N Maeda Shintaro S Iwasaki Kenji K Nakagawa Atsushi A Yamashita Eiki E
Nature communications 20190403 1
In Pseudomonas aeruginosa, MexAB-OprM plays a central role in multidrug resistance by ejecting various drug compounds, which is one of the causes of serious nosocomial infections. Although the structures of the components of MexAB-OprM have been solved individually by X-ray crystallography, no structural information for fully assembled pumps from P. aeruginosa were previously available. In this study, we present the structure of wild-type MexAB-OprM in the presence or absence of drugs at near-at ...[more]
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