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Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go

ABSTRACT:

SUBMITTER: Christopher Tate

PROVIDER: EMPIAR-10308 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.

García-Nafría Javier J Nehmé Rony R Edwards Patricia C PC Tate Christopher G CG

Nature 20180620 7711

G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to a small number of heterotrimeric G proteins (16 genes encoding different α-subunits). Each human cell contains several GPCRs and G proteins. The structural determinants of coupling of Gs to four different GPCRs have been elucidated1-4, but the molecular details of how the other G-protein classes couple to GPCRs are un ...[more]

PMID: 29925951

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