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Human delta protocadherin 1 full ectodomains on membranes, tomogram 3

ABSTRACT:

SUBMITTER: Lawrence Shapiro

PROVIDER: EMPIAR-10369 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.

Harrison Oliver J OJ Brasch Julia J Katsamba Phinikoula S PS Ahlsen Goran G Noble Alex J AJ Dan Hanbin H Sampogna Rosemary V RV Potter Clinton S CS Carragher Bridget B Honig Barry B Shapiro Lawrence L

Cell reports 20200201 8

Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of δ1- and δ2-protocadherins, determined crystal structures of ectodomain complexes from each family, and assessed ectodomain assembly in reconstituted intermembrane junctions by cryoelectron tomography (cry ...[more]

PMID: 32101743

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