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Structure of replicating SARS-CoV-2 polymerase

ABSTRACT:

SUBMITTER: Patrick Cramer

PROVIDER: EMPIAR-10409 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure of replicating SARS-CoV-2 polymerase.

Hillen Hauke S HS Kokic Goran G Farnung Lucas L Dienemann Christian C Tegunov Dimitry D Cramer Patrick P

Nature 20200521 7819

The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes<sup>1-3</sup>. Here we present a cryo-electron microscopy structure of the SARS-CoV-2 RdRp in an active form that mimics the replicating enzyme. The structure comprises the viral proteins non-structural protein 12 (nsp12), nsp8 and nsp7, and more than two turns of RNA template-product duplex. The active-s ...[more]

PMID: 32438371

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