Ontology highlight
ABSTRACT:
SUBMITTER: Kirchdoerfer RN
PROVIDER: S-EPMC6538669 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kirchdoerfer Robert N RN Ward Andrew B AB
Nature communications 20190528 1
Recent history is punctuated by the emergence of highly pathogenic coronaviruses such as SARS- and MERS-CoV into human circulation. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the replication and transcription of the viral genome. Here, we present the 3.1 Å resolution structure of the SARS-CoV nsp12 polymerase bound to its essential co-factors, nsp7 and nsp8, using single particle cryo-electron mic ...[more]