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Subtomogram averaging and classification of SARS-CoV-2 Spike Proteins on intact virions

ABSTRACT:

SUBMITTER: Zunlong Ke

PROVIDER: EMPIAR-10493 | biostudies-other |

REPOSITORIES: biostudies-other

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Structures and distributions of SARS-CoV-2 spike proteins on intact virions.

Ke Zunlong Z Oton Joaquin J Qu Kun K Cortese Mirko M Zila Vojtech V McKeane Lesley L Nakane Takanori T Zivanov Jasenko J Neufeldt Christopher J CJ Cerikan Berati B Lu John M JM Peukes Julia J Xiong Xiaoli X Kräusslich Hans-Georg HG Scheres Sjors H W SHW Bartenschlager Ralf R Briggs John A G JAG

Nature 20200817 7838

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude<sup>1</sup>. Heavily glycosylated S trimers bind to the angiotensin-converting enzyme 2 receptor and mediate entry of virions into target cells<sup>2-6</sup>. S exhibits extensive conformational flexibility: it modulates exposure of its receptor-binding site and subsequently undergoes complete structural rearrangement to drive fusion of viral and ce ...[more]

PMID: 32805734

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