Dataset Information
Subtomogram averaging and classification of SARS-CoV-2 Spike Proteins on intact virions
Ontology highlight
ABSTRACT:
SUBMITTER: Zunlong Ke
PROVIDER: EMPIAR-10493 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structures and distributions of SARS-CoV-2 spike proteins on intact virions.
Nature 20200817 7838
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude<sup>1</sup>. Heavily glycosylated S trimers bind to the angiotensin-converting enzyme 2 receptor and mediate entry of virions into target cells<sup>2-6</sup>. S exhibits extensive conformational flexibility: it modulates exposure of its receptor-binding site and subsequently undergoes complete structural rearrangement to drive fusion of viral and ce ...[more]