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Cryo-EM structures of four polymorphic TDP-43 amyloid cores

ABSTRACT:

SUBMITTER: David R Boyer

PROVIDER: EMPIAR-10497 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM structures of four polymorphic TDP-43 amyloid cores.

Cao Qin Q Boyer David R DR Sawaya Michael R MR Ge Peng P Eisenberg David S DS

Nature structural & molecular biology 20190624 7

The DNA and RNA processing protein TDP-43 undergoes both functional and pathogenic aggregation. Functional TDP-43 aggregates form reversible, transient species such as nuclear bodies, stress granules, and myo-granules. Pathogenic, irreversible TDP-43 aggregates form in amyotrophic lateral sclerosis and other neurodegenerative conditions. Here we find the features of TDP-43 fibrils that confer both reversibility and irreversibility by determining structures of two segments reported to be the path ...[more]

PMID: 31235914

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