Dataset Information
E. coli 50S ribosome bound to compounds 46 and VS1
Ontology highlight
ABSTRACT:
SUBMITTER: James Fraser
PROVIDER: EMPIAR-10530 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Synthetic group A streptogramin antibiotics that overcome Vat resistance.
Nature 20200923 7827
Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class of antibiotics<sup>1</sup>. Virginiamycin acetyltransferase (Vat) enzymes are resistance proteins that provide protection against streptogramins<sup>2</sup>, potent antibiotics against Gram-positive bacteria that inhibit the bacterial ...[more]