Dataset Information
Cryo-ET of actin bundles induced by full length vinculin
Ontology highlight
ABSTRACT:
SUBMITTER: Ohad Medalia
PROVIDER: EMPIAR-10548 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Talin-activated vinculin interacts with branched actin networks to initiate bundles.
eLife 20201113
Vinculin plays a fundamental role in integrin-mediated cell adhesion. Activated by talin, it interacts with diverse adhesome components, enabling mechanical coupling between the actin cytoskeleton and the extracellular matrix. Here we studied the interactions of activated full-length vinculin with actin and the way it regulates the organization and dynamics of the Arp2/3 complex-mediated branched actin network. Through a combination of surface patterning and light microscopy experiments we show ...[more]