Actin filament structure from focal adhesions of mouse embryonic fibroblasts
Ontology highlight
ABSTRACT:
SUBMITTER: Matthias Eibauer
PROVIDER: EMPIAR-10570 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Unveiling the polarity of actin filaments by cryo-electron tomography.
Martins Bruno B Sorrentino Simona S Chung Wen-Lu WL Tatli Meltem M Medalia Ohad O Eibauer Matthias M
Structure (London, England : 1993) 20210120 5
The actin cytoskeleton plays a fundamental role in numerous cellular processes, such as cell motility, cytokinesis, and adhesion to the extracellular matrix. Revealing the polarity of individual actin filaments in intact cells would foster an unprecedented understanding of cytoskeletal processes and their associated mechanical forces. Cryo-electron tomography provides the means for high-resolution structural imaging of cells. However, the low signal-to-noise ratio of cryo-tomograms obscures the ...[more]
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